Intravenous compatibility chart drug information for the. Critically analyse the potential complications associated with iv therapy and discuss appropriate actions to prevent andor treat these complications. All patients require serumvancomycin measurement on the second day of treatment, immediately before the next dose if renal function normal, earlier if renal impairmentconsult product literature. Drug interactions are reported among people who take vancomycin hydrochloride and zosyn together. Does the combination of vancomycin and piperacillin. Vancomycin and piperacillintazobactam combination therapy. Simulated ysite compatibility of vancomycin and piperacillin. Vancomycin hydrochloride fda prescribing information. Systemic vancomycin exposure may result in acute kidney injury aki and interstitial nephritis. For patients with a creatinine clearance between 2040 mlminute, the dose of zosyn should be 2.
Zosyn and infection cipro and infection zosyn and fever cipro and pain zosyn and vancomycin cipro and uti zosyn and allergy. Intravenous compatibility chart acyclovir acyclovir. Intravenous compatibility chart drug information for. Does vancomycin plus piperacillintazobactam equal more kidney injury. Zosyn should be administered by intravenous infusion over 30 minutes. Demonstrate the safe handling of equipment used in iv therapy, e. Vancomycin and piperacillintazobactam were tested using simulated and actual ysite infusion methodologies.
The compatibility of ertapenem, tigecycline, colistin, daptomycin, vancomycin and teicoplanin was researched with all medications used in our surgery using the lamlamellar technique and visual. Extendedinfusion piperacillintazobactam zosyn compatibility. Remember my login on this computer forgot your password. Zosyn fda prescribing information, side effects and uses. Vancomycin concentrations at or exceeding 20 mgml are incompatible with all concentrations of ptz. There is only 2 iv antibiotics that will treat his. This medication is usually given by injection into a vein. Original article simulated ysite compatibility of vancomycin and. Incompatibilities formed a white precipitate immediately on mixing. Ysite compatibility of vancomycin and piperacillin. Incompatibilities are based on meeting any of the following criteria. This study is created by ehealthme based on reports of 168 people who take vancomycin hydrochloride and zosyn from the food and drug administration fda, and is updated regularly. Combination vancomycin van and piperacillintazobactam ptz is an oftenused empirical antibiotic regimen for severe infections in hospitalized.
Rapid iv administration may result in flushing, pruritus, hypotension, erythema, and urticaria. The purpose of this study was to evaluate ysite compatibility of vancomycin with piperacillintazobactam diluted with either 0. Vancomycin hydrochloride for injection, usp is a white, almost white, or tan lyophilized powder, for preparing intravenous iv infusions, in pharmacy bulk package bottles containing the equivalent of 5 or 10 g vancomycin base. Coadministration of zosyn with vancomycin may increase the receiving zosyn and vancomycin. Ucla health antimicrobial stewardship program log in. Published vancomycin and pt compatibility data, describing varying concentrations of each drug, demonstrate inconsistent results. The arm with the is is now swollen, firm with a bumpy rah and weeping. Warning label what does clomid 50mg success rate levaquin and vancomycin iv compatibility can i.
Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Keywords compatibility, piperacillintazobactam, vancomycin, ysite, zosyn. Frequency of monitoring depends on the clinical situation and response to treatment. Key wordscompatibility, piperacillintazobactam, vancomycin, ysite, zosyn hosp pharm2015. We look into the drug interactions by gender and age. Recent studies have also identified compatibility issues with different concentrations of vancomycin and piperacillintazobactam 74757677 78. Vancomycin and zosyn nephrotoxicity doctor answers on. Vancomycin is used to treat serious bacterial infections. Compare vancomycin vs zosyn comprehensive analysis by treato. Learn about drug interactions between acyclovir oral and vancomycin iv and use the rxlist drug interaction checker to check drug combinations.
Physical compatibility of vancomycin and piperacillin. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. Initial presumptive treatment of patients with nosocomial pneumonia should start with zosyn at a dosage of 4. For patients with a creatinine clearance less than 20 mlminute, the dose should be 2. Vancomycin 10 mgml was incompatible with piperacillintazobactam 40, 80, and 100 mgml.
Iv ysite infusion solutioncompatibility data infusion solution compatible. For additional information or clarification, call pharmacy. When dextrose 5% for injection was used as the diluent, vancomycin 4 mgml was ysite compatible with piperacillintazobactam 16, 30, and 40 mgml. Ysite incompatibility was seen immediately in the form of a white precipitate on mixing. Zosyn should be administered by intravenous infusion over 30. Vancomycin and piperacillintazobactam are common empiric antibiotics in hospitalized pediatric patients. Oral equivalent of zosyn doctor answers on healthcaremagic.
Request pdf ysite compatibility of vancomycin and piperacillintazobactam at commonly utilized pediatric concentrations vancomycin and. Trissel, fashp, 2010, american society of healthsystem pharmacists. The usual total daily dose of zosyn for adults is 3. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Ysite injection drug compatibility chart for general. Ptz concentrations of 45 mgml are compatible with vancomycin concentrations of mic with the same dose 2. Does vancomycin plus piperacillintazobactam equal more.
Acute kidney injury with antibiotic combinations and. Ysite compatibility of vancomycin and piperacillin tazobactam at commonly utilized pediatric concentrations authors kristen r. Right before noras birth i was also given vancomycin, zosyn multiple times because they thought i had. Pdf ysite incompatibility between premix concentrations of. Vancomycin hydrochloride and zosyn drug interactions. Pdf download for simulated ysite compatibility of vancomycin and. Vancomycin hydrochloride and piperacillin sodium tazobactam were reconstituted with 0. Identify issues surrounding stability and compatibility of iv therapies. Physical compatibility of vancomycin and piperacillin sodium. Ysite injection drug compatibility chart for general wards. The usual duration of zosyn treatment is from 7 to 10 days. Iv ozone, high dose vitamin c booklet index page no.